English: Bisbiguanide with bacteriostatic activity. Prepn: Rose, Swain, J. Chem. Soc. 1956, 4422; eidem, US 2684924 (1954 to I.C.I.). Antibacterial activity and acute toxicity: G. E. Davies et al., Br. J. Pharmacol. 9, 192 (1954). Review of toxicology and clinical uses: D. M. Foulkes, J. Periodontal Res. 8, Suppl. 12, 55-60 (1973). Series of articles on clinical efficacy in gingivitis and plaque control: ibid. 21, Suppl. 16, 1-89 (1986).